Blar i forfatter "Haugaard-Kedström, Linda M."

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    • A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 

      Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-15)
      Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin as an activator of native C5 by analyzing complement activation and C5 cleavage in human whole blood anticoagulated with Gly-Pro-Arg-Pro (GPRP), a peptide ...

    • A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma 

      Haugaard-Kedström, Linda M.; Clemmensen, Louise S.; Sereikaite, Vita; Jin, Zeyu; Fernandes, Eduardo F. A.; Wind, Bianca; Abalde-Gil, Flor; Daberger, Jan; Vistrup-Parry, Maria; Aguilar-Morante, Diana; Leblanc, Raphael; Egea-Jimenez, Antonio L.; Albrigtsen, Marte; Jensen, Kamilla E.; Jensen, Thomas M. T.; Ivarsson, Ylva; Vincentelli, Renaud; Hamerlik, Petra; Andersen, Jeanette Hammer; Zimmermann, Pascale; Lee, Weonate; Strømgaard, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-27)
      Despite the recent advances in cancer therapeutics, highly aggressive cancer forms, such as glioblastoma (GBM), still have very low survival rates. The intracellular scaffold protein syntenin, comprising two postsynaptic density protein-95/discs-large/zona occludens-1 (PDZ) domains, has emerged as a novel therapeutic target in highly malignant phenotypes including GBM. Here, we report the development ...